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JUHA E JÄÄSKELÄINEN


    +358 44 717 4660
    juha.e.jaaskelainen (at) kuh.fi
    www.kuopioneurosurgery.fi

    www.kuopioneurokeskus.fi
    www.psshp.fi
   
Present positions
    Professor of Neurosurgery / UEF University of Eastern Finland  2004 –
    Chairman of Neurosurgery / KUH NeuroCenter / Kuopio University Hospital  2004 –
    KUH Neuro-Oncology Group

Previous positions
    Neurosurgery / Helsinki University Hospital
        * Resident  1978 – 85
        * Staff Neurosurgeon  1986 – 91
        * Lecturer of Neurosurgery  1992 – 00
        * Acting Professor of Neurosurgery  1994 – 95
        * Head of Department  2001 – 2004

Academic degrees
    MD  1977 – Medical School / Kuopio University / Finland
    Neurosurgeon  1985 – Neurosurgery / Helsinki University / Finland
    PhD  1986 – Neurosurgery and Neuropathology / Helsinki University
        * Intracranial Meningioma: Factors Affecting Recurrence / Prof Matti Haltia
    Docent of Neurosurgery  1995 – Helsinki University
    Professor of Neurosurgery  2004 – UEF University of Eastern Finland

Visiting Professor
    2001–2  Neurosurgery / Brigham and Women’s Hospital / Harvard Medical School

Main scientific positions of trust
    Cancer Society of Finland – Evaluation Committees of Cancer Research Grants
        * Member – Basic Cancer Research  2009 – 2011
        * Chairman – Clinical Cancer Research  2011 –
    Scandinavian Neurosurgical Society
        * Lecturer in Training Courses for neurosurgery residents  2003 –
    EANS European Association of Neurosurgical Societies
        * Member of EANS Neurooncology Committee  1996 – 03
        * Member of EANS Research Committee  2003 –
        * Lecturer in EANS Training Courses for neurosurgery residents
    Acta Neurochirurgica / EANS journal
        * Editorial board member 2009 –
 
Research and development / UEF University of Eastern Finland  2004 –
    Kuopio Intracranial Aneurysm Research Group  www.uef.fi/ns
    Kuopio NPH and Early Alzheimer Disease Group www.uef.fi/nph
    Development of pre / intraoperative brain mapping www.medi-imaging.org
    Development of pre / intraoperative brain mapping

Scientific original articles in international peer-reviewed journals
    125 in total – 54 on intracranial aneurysms – 71 on neuro-oncology

Supervision of PhD theses
    6 completed –12 in progress

Adviser for medical technology manufacturers

Elekta Neuromag (former Neuromag), Helsinki www.elekta.com
  * neurosurgical applications of magnetoencephalography (MEG)

NexStim, Helsinki  www.nexstim.com
  * contact Henri Hannula
  * neurosurgical applications of navigated transcranial magnetic stimulation

Clinical experience in neuro-oncology

Member of multidisciplinary neuro-oncology group
    Helsinki University Hospital  2000 – 4
    Kuopio University Hospital  2004 –

Microsurgery of intracranial tumours supplemented by brain mapping techniques
    preoperative functional brain mapping
    intraoperative electric stimulation mapping
    awake craniotomy

Stereotactic techniques
    biopsies and catheter placements
    intratumoural implantation of 1-125 isotope seeds

Stereotactic radiotherapy with linear accelerator
    Helsinki University Hospital  1996 – 2004
    Kuopio University Hospital  2004 –
    KUH CyberKnife since III 2012

Inherited CNS tumour traits
    Neurofibromatosis 1 (NF1)
    Neurofibromatosis 2 (NF2)
    von Hippel-Lindau disease (VHL)

Author of 71 scientific articles on neuro-oncology
   
Author of domestic neuro-oncology chapters / Duodecim Kustannus
    Keskushermoston kasvaimet / Neurologia-kirja 2011
    Kallonsisäiset kasvaimet / Kirurgia-kirja 2010
    Keskushermoston kasvaimet / Syöpätaudit-kirja 2007
    Stereotaktinen sädehoito kallon alueelle / Duodecim-lehti 2008

 
Peer-reviewed original articles
H-index = 36
Articles cited >100 times = 12

2011

Anna P, Niemelä M, van Popta J, Matti P, Kangasniemi M, Rinne J, Jääskeläinen J, Hernesniemi J. Management of 251 patients with dural arteriovenous fistulas - Helsinki and Kuopio experience 1944-2006. (submitted)

Pyykkö OT, Helisalmi S, Koivisto AM, Mölsä JAA, Rummukainen J, Nerg O, Alafuzoff I, Savolainen S, Soininen H, Jääskeläinen JE, Rinne J, Leinonen V, Hiltunen M. APOE4 predicts amyloid-β in cortical brain biopsy but exhibits a nonexistant role in idiopathic normal pressure hydrocephalus. Journal of Neurology Neurosurgery Psychiatry (re-submitted)

Koivisto AM, Alafuzoff I, Savolainen S, Sutela A, Rummukainen J, Vanninen R, Jääskeläinen JE, Soininen H, Rinne J, Leinonen V. Subsequent dementia in initially shunt-responsive patients with idiopathic normal pressure hydrocephalus. Journal of Neurology Neurosurgery Psychiatry (submitted)

Gaál EA, Salo P, Kristiansson K, Rehnström K,  Kettunen J, Niemelä M, Nieminen MS, Sinisalo J, Lokki M-L, Jula A, Raitakari O, Lehtimäki T, Eriksson JG, Widen E, Günel M, Kurki M, von und zu Fraunberg M, Jääskeläinen JE, Hernesniemi J, The International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS), Palotie A, Salomaa V, Perola M. Intracranial Aneurysm risk locus 5q23•2 is associated with elevated systolic blood pressure. PloS Genetics (re-submitted)

125. TT Seppälä, O Nerg, AM Koivisto, Rummukainen J, Puli LM,  Zetterberg H, Pyykkö, OT, Helisalmi S, Alafuzoff I, Hiltunen M, Jääskeläinen JE, Rinne J, Soininen H, Leinonen V, Herukka S-K. Ventricular and lumbar CSF biomarkers for Alzheimer’s disease correlate with cortical brain biopsy findings. Neurology (in press)

124. Yasuno K, Bakircioglu M, Low S-K, Bilguvar K, Gaál E, Ruigrok YM, Niemela M, Hata A, Bijlenga P, Kasuya H, Jääskeläinen JE, Krex D, Auburger G, Simon M, Krischek B, Ozturk AK, Mane S, Steinmetz H, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Murat Günel M.  A common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk. PNAS 2011 www.pnas.org/cgi/doi/10.1073/pnas.1117137108

123. Leinonen V, Koivisto AM, Alafuzoff I, Pyykkö OT, Rummukainen J, von und zu Fraunberg M, Jääskeläinen JE, Soininen H, Rinne, Savolainen S. Cortical brain biopsy in long-term prognostication of 468 patients with possible normal pressure hydrocephalus. Neurodegenerative Diseases (in press)

122. Huttunen T, Riihinen A, Pukkala E, von und zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Sankila R, Jääskeläinen JE. Increased relative risk of lung cancer in 2 904 patients with saccular intracranial aneurysm disease in Eastern Finland. Neuroepidemiology (in press)

121. Soppi V, Karamanakos PN, Koivisto T, Vanninen R, Jaaskelainen JE, Rinne J. A randomized outcome study of enteral versus intravenous nimodipine in 171 patients after acute aneurysmal subarachnoid hemorrhage. World Neurosurgery (in press)

120. Lindgren A, Huttunen T, Saavalainen T, Riihinen A, Kurki MI, Koivisto T, Ronkainen A, Rinne J, Hernesniemi J, Jääskeläinen JE, von und zu Fraunberg M. Increased incidence of aneurysmal subarachnoid hemorrhage on Sundays and Mondays in 1862 patients from Eastern Finland. Neuroepidemiology (in press)

119. Coco K, Tossavainen K, Jääskeläinen JE, Turunen H. Support for Traumatic Brain Injury Patients' Family Members in Neurosurgical Nursing: A Systematic Review. J Neurosci Nurs 2011;43:337-348

118. Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Sutela A, Vanninen R, Jääskeläinen JE, Soininen H, Alafuzoff I. Post-mortem findings in 10 patients with presumed normal pressure hydrocephalus and review of the literature.Neuropathol Appl Neurobiol 2011 Jun 23. doi: 10.1111/j.1365-2990.2011.01195.x.

117. Leinonen V, Menon LG, Carroll RS, Dello Iacono D, Grevet J, Jääskeläinen JE, Black PM. Cerebrospinal fluid biomarkers in idiopathic normal pressure hydrocephalus. Int J Alzheimers Dis 2011;2011:312526

116. Kurki MI, Paananen J, Storvik M, Ylä-Herttuala S, Jääskeläinen JE, von Und Zu Fraunberg M, Wong G, Pehkonen P. TAFFEL: Independent Enrichment Analysis of gene sets. BMC Bioinformatics 2011;12:171

115. Kurki MI, Häkkinen SK, Frösen J, Tulamo R, von und zu Fraunberg M, Wong G, Tromp G, Niemelä M, Hernesniemi J, Jääskeläinen JE, Ylä-Herttuala S. Upregulated signaling pathways in ruptured human saccular intracranial aneurysm wall: an emerging regulative role of Toll-like receptor signaling and nuclear factor-κB, hypoxia-inducible factor-1A, and ETS transcription factors. Neurosurgery 2011;68:1667-75

114. Huttunen T, von und Zu Fraunberg M, Koivisto T, Ronkainen A, Rinne J, Sankila R, Seppä K, Jääskeläinen JE. Long-term excess mortality of 244 familial and 1502 sporadic one-year survivors of aneurysmal subarachnoid hemorrhage compared with a matched Eastern Finnish catchment population. Neurosurgery 2011;68:20-7

2010

113. Leinonen V, Koivisto AM, Savolainen S, Rummukainen J, Tamminen JN, Tillgren T, Vainikka S, Pyykkö OT, Mölsä J, Fraunberg M, Pirttilä T, Jääskeläinen JE, Soininen H, Rinne J, Alafuzoff I. Amyloid and tau proteins in cortical brain biopsy and Alzheimer's disease. Ann Neurol 2010;68:446-53
IF = 9.3

112. Lehecka M, Dashti R, Laakso A, van Popta JS, Romani R, Navratil O, Kivipelto L, Kivisaari R, Foroughi M, Kokuzawa J, Lehto H, Niemelä M, Rinne J, Ronkainen A, Koivisto T, Jääskelainen JE, Hernesniemi J. Microneurosurgical management of anterior choroid artery aneurysms. World Neurosurg 2010;73:486-99

111. Säisänen L, Könönen M, Julkunen P, Määttä S, Vanninen R, Immonen A, Jutila L, Kälviäinen R, Jääskeläinen JE, Mervaala E. Non-invasive preoperative localization of primary motor cortex in epilepsy surgery by navigated transcranial magnetic stimulation. Epilepsy Res 2010;92(2-3):134-44

110. Leu M, Humphreys K, Surakka I, Rehnberg E, Muilu J, Rosenström P, Almgren P, Jääskeläinen J, Lifton RP, Kyvik KO, Kaprio J, Pedersen NL, Palotie A, Hall P, Grönberg H, Groop L, Peltonen L, Palmgren J, Ripatti S. NordicDB: a Nordic pool and portal for genome-wide control data. Eur J Hum Genet 2010;18:1322-6

109. Karamanakos PN, Koivisto T, Vanninen R, Khallaf M, Ronkainen A, Parviainen I, Manninen H, von und zu Fraunberg M, Morgan MK, Jaaskelainen JE, Hernesniemi J, Rinne J. The impact of endovascular management on the outcome of aneurysmal subarachnoid hemorrhage in the elderly in eastern Finland. Acta Neurochir 2010;152:1493-502

108. Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, Niemelä M, Tajima A, von und zu Fraunberg  M, Dóczi T, Wirjatijasa F, Hata A, Blasco J, Oszvald A, Kasuya H, Zilani G, Schoch B, Singh P, Stüer C, Risselada R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, van Duijn CM, van den Berg LH, Perret C, Proust C, Roder C, Ozturk AK, Gaál E, Berg D, Geisen C, Friedrich CM, Summers P, Frangi AF, State MW, Wichmann HE, Breteler MM, Wijmenga C, Mane S, Peltonen L, Elio V, Sturkenboom MC, Lawford P, Byrne J, Macho J, Sandalcioglu EI, Meyer B, Raabe A, Steinmetz H, Rüfenacht D, Jääskeläinen JE, Hernesniemi J, Rinkel GJ, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Günel M. Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nat Genet 2010;42:420-5

107. Karamanakos PN, Jaaskelainen JE, Alafuzoff I, Pirinen E, Vanninen R, Silvennoinen S, Sankilampi U, Immonen A. Malignant giant cell tumor in the posterior fossa of a neonate. J Neurosurg Pediatr 2010;5:277-82

106. Huttunen T, von und zu Fraunberg M, Frösen J, Lehecka M, Tromp G, Helin K, Koivisto T, Rinne J, Ronkainen A, Hernesniemi J, Jääskeläinen JE. Saccular intracranial aneurysm disease: distribution of site, size, and age suggests different etiologies for aneurysm formation and rupture in 316 familial and 1454 sporadic eastern Finnish patients. Neurosurgery 2010;66:631-8

105. Celik O, Piippo A, Romani R, Navratil O, Laakso A, Lehecka M, Dashti R, Niemelä M, Rinne J, Jääskeläinen JE, Hernesniemi J. Management of dural arteriovenous fistulas - Helsinki and Kuopio experience. Acta Neurochir Suppl 2010;107:77-82

2009

104. Karamanakos PN, Varis J, Ronkainen A, Koivisto T, Rinne J, Jaaskelainen JE. Chronic subdural haematoma after endoscopic treatment of a supracellar arachnoid cyst. Acta Neurol Belg 2009;109:149-51

103. Romani R, Lehecka M, Gaal E, Toninelli S, Celik O, Niemelä M, Porras M, Jääskeläinen J, Hernesniemi J. Lateral supraorbital approach applied to olfactory groove meningiomas: experience with 66 consecutive patients. Neurosurgery 2009;65:39-52

102. Myllymaa S, Myllymaa K, Korhonen H, Töyräs J, Jääskeläinen JE, Djupsund K, Tanila H, Lappalainen R. Fabrication and testing of polyimide-based microelectrode arrays for cortical mapping of evoked potentials. Biosens Bioelectron 2009;24:3067-72

101. Lehecka M, Dashti R, Romani R, Celik O, Navratil O, Kivipelto L, Kivisaari R, Shen H, Ishii K, Karatas A, Lehto H, Kokuzawa J, Niemelä M, Rinne J, Ronkainen A, Koivisto T, Jääskelainen JE, Hernesniemi J. Microneurosurgical management of internal carotid artery bifurcation aneurysms. Surg Neurol 2009;71:649-67

2008

100. Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, von Und Zu Fraunberg M, van Duijn CM, van den Berg LH, Mane S, Mason CE, Choi M, Gaál E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Ohman J, Breteler MM, Wijmenga C, State MW, Rinkel GJ, Hernesniemi J, Jääskeläinen JE, Palotie A, Inoue I, Lifton RP, Günel M. Susceptibility loci for intracranial aneurysm in European and Japanese populations. Nat Genet 2008;40:1472-7

99. Leinonen V, Alafuzoff I, Aalto S, Suotunen T, Savolainen S, Någren K, Tapiola T, Pirttilä T, Rinne J, Jääskeläinen JE, Soininen H, Rinne JO. Assessment of beta-amyloid in a frontal cortical brain biopsy specimen and by positron emission tomography with carbon 11-labeled Pittsburgh Compound B. Arch Neurol 2008;65:1304-9

98. Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at the A2 segment of anterior cerebral artery (proximal pericallosal artery) and its frontobasal branches. Surg Neurol 2008;70:232-46

97. Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at A3 segment of anterior cerebral artery. Surg Neurol 2008;70:135-51

96. Lehecka M, Dashti R, Hernesniemi J, Niemelä M, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen J. Microneurosurgical management of aneurysms at A4 and A5 segments and distal cortical branches of anterior cerebral artery. Surg Neurol 2008;70:352-67

95. Hernesniemi J, Dashti R, Lehecka M, Niemelä M, Rinne J, Lehto H, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of anterior communicating artery aneurysms. Surg Neurol 2008;70:8-28

94. Lehecka M, Lehto H, Niemelä M, Juvela S, Dashti R, Koivisto T, Ronkainen A, Rinne J, Jääskeläinen JE, Hernesniemi JA. Distal anterior cerebral artery aneurysms: treatment and outcome analysis of 501 patients. Neurosurgery 2008;62:590-601

93. Helgadottir A, Thorleifsson G, Magnusson KP, Grétarsdottir S, Steinthorsdottir V, Manolescu A, Jones GT, Rinkel GJ, Blankensteijn JD, Ronkainen A, Jääskeläinen JE, Kyo Y, Lenk GM, Sakalihasan N, Kostulas K, Gottsäter A, Flex A, Stefansson H, Hansen T, Andersen G, Weinsheimer S, Borch-Johnsen K, Jorgensen  T, Shah SH, Quyyumi AA, Granger CB, Reilly MP, Austin H, Levey AI, Vaccarino V, Palsdottir E, Walters GB, Jonsdottir T, Snorradottir S, Magnusdottir D, Gudmundsson G, Ferrell RE, Sveinbjornsdottir S, Hernesniemi J, Niemelä M, Limet R, Andersen K, Sigurdsson G, Benediktsson R, Verhoeven EL, Teijink JA, Grobbee DE, Rader DJ, Collier DA, Pedersen O, Pola R, Hillert J, Lindblad B, Valdimarsson EM, Magnadottir HB, Wijmenga C, Tromp G, Baas AF, Ruigrok YM, van Rij AM, Kuivaniemi H, Powell JT, Matthiasson SE, Gulcher JR, Thorgeirsson G, Kong A, Thorsteinsdottir U, Stefansson K. The same sequence variant on 9p21 associates with myocardial infarction, abdominal aortic aneurysm and intracranial aneurysm. Nat Genet 2008;40:217-24

2007

92. Mäkelä JP, Forss N, Jääskeläinen J, Kirveskari E, Korvenoja A, Paetau R. Magnetoencephalography in neurosurgery. Neurosurgery 2007;61(1 Suppl):147-64

91. Dashti R, Hernesniemi J, Lehto H, Niemelä M, Lehecka M, Rinne J, Porras M, Ronkainen A, Phornsuwannapha S, Koivisto T, Jääskeläinen JE. Microneurosurgical management of proximal anterior cerebral artery aneurysms. Surg Neurol 2007;68:366-77

90. Weinsheimer S, Goddard KA, Parrado AR, Lu Q, Sinha M, Lebedeva ER, Ronkainen A, Niemelä M, Khusnutdinova EK, Khusainova RI, Helin K, Jääskeläinen JE, Sakovich VP, Land S, Kuivaniemi H, Tromp G. Association of kallikrein gene polymorphisms with intracranial aneurysms. Stroke 2007;38:2670-6

89. Larjavaara S, Mäntylä R, Salminen T, Haapasalo H, Raitanen J, Jääskeläinen J, Auvinen A. Incidence of gliomas by anatomic location. Neuro Oncol 2007;9:319-25

88. Dashti R, Hernesniemi J, Niemelä M, Rinne J, Lehecka M, Shen H, Lehto H, Albayrak BS, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of distal middle cerebral artery aneurysms. Surg Neurol 2007;67:553-63

87. Dashti R, Hernesniemi J, Niemelä M, Rinne J, Porras M, Lehecka M, Shen H, Albayrak BS, Lehto H, Koroknay-Pál P, de Oliveira RS, Perra G, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of middle cerebral artery bifurcation aneurysms. Surg Neurol 2007;67:441-56

86. Frösen J, Pitkäniemi J, Tulamo R, Marjamaa J, Isoniemi H, Niemelä M, Jääskeläinen J, Lokki ML, Matinlauri I. Association of fatal aneurysmal subarachnoid hemorrhage with human leukocyte antigens in the Finnish population. Hum Immunol 2007;68:100-5

85. Lehecka M, Niemelä M, Seppänen J, Lehto H, Koivisto T, Ronkainen A, Rinne J, Sankila R, Jääskeläinen J, Hernesniemi J. No long-term excess mortality in 280 patients with ruptured distal anterior cerebral artery aneurysms. Neurosurgery 2007;60:235-40

84. Dashti R, Rinne J, Hernesniemi J, Niemelä M, Kivipelto L, Lehecka M, Karatas A, Avci E, Ishii K, Shen H, Peláez JG, Albayrak BS, Ronkainen A, Koivisto T, Jääskeläinen JE. Microneurosurgical management of proximal middle cerebral artery aneurysms. Surg Neurol 2007;67:6-14

83. Havu-Aurén K, Kiiski J, Lehtiö K, Eskola O, Kulvik M, Vuorinen V, Oikonen V,  Vähätalo J, Jääskeläinen J, Minn H. Uptake of 4-borono-2-[18F]fluoro-L-phenylalanine in sporadic and neurofibromatosis 2-related schwannoma and meningioma studied with PET. Eur J Nucl Med Mol Imaging 2007;34:87-94
IF = 4.5

2006

82. Hernesniemi J, Niemelä M, Dashti R, Karatas A, Kivipelto L, Ishii K, Rinne J, Ronkainen A, Peláez JG, Koivisto T, Kivisaari R, Shen H, Lehecka M, Frösen J, Piippo A, Avci E, Jääskeläinen JE. Principles of microneurosurgery for safe and fast surgery. Surg Technol Int 2006;15:305-10

81. Tulamo R, Frösen J, Junnikkala S, Paetau A, Pitkäniemi J, Kangasniemi M, Niemelä M, Jääskeläinen J, Jokitalo E, Karatas A, Hernesniemi J, Meri S. Complement activation associates with saccular cerebral artery aneurysm wall degeneration and rupture. Neurosurgery 2006;59:1069-76

80. Mäkelä JP, Forss N, Jääskeläinen J, Kirveskari E, Korvenoja A, Paetau R. Magnetoencephalography in neurosurgery. Neurosurgery 2006;59:493-510

79. Korvenoja A, Kirveskari E, Aronen HJ, Avikainen S, Brander A, Huttunen J, Ilmoniemi RJ, Jääskeläinen JE, Kovala T, Mäkelä JP, Salli E, Seppä M. Sensorimotor cortex localization: comparison of magnetoencephalography, functional MR imaging, and intraoperative cortical mapping. Radiology 2006;241:213-22

78. Frösen J, Marjamaa J, Myllärniemi M, Abo-Ramadan U, Tulamo R, Niemelä M, Hernesniemi J, Jääskeläinen J. Contribution of mural and bone marrow-derived neointimal cells to thrombus organization and wall remodeling in a microsurgical murine saccular aneurysm model. Neurosurgery 2006;58:936-44

77. Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, Hernesniemi J, Jääskeläinen J. Growth factor receptor expression and remodeling of saccular cerebral artery aneurysm walls: implications for biological therapy preventing rupture. Neurosurgery 2006 Mar;58(3):534-41

76. Nagy L, Ishii K, Karatas A, Shen H, Vajda J, Niemelä M, Jääskeläinen J, Hernesniemi J, Toth S. Water dissection technique of Toth for opening neurosurgical cleavage planes. Surg Neurol 2006;65(1):38-41

2005

75. Timonen M, Kankaanranta L, Lundbom N, Collan J, Kangasmäki A, Kortesniemi M, Häkkinen AM, Lönngren A, Karjalainen S, Rasilainen M, Leinonen J, Huitti T, Jääskeläinen J, Kouri M, Savolainen S, Heikkinen S. 1H MRS studies in the Finnish boron neutron capture therapy project: detection of 10B-carrier, L-p-boronophenylalanine-fructose. Eur J Radiol 2005;56:154-9

74. Hernesniemi J, Niemelä M, Karatas A, Kivipelto L, Ishii K, Rinne J, Ronkainen A, Koivisto T, Kivisaari R, Shen H, Lehecka M, Frösen J, Piippo A, Jääskeläinen JE. Some collected principles of microneurosurgery: simple and fast, while preserving normal anatomy: a review. Surg Neurol 2005;64:195-200

73. Niemelä M, Koivisto T, Kivipelto L, Ishii K, Rinne J, Ronkainen A, Kivisaari R, Shen H, Karatas A, Lehecka M, Frösen J, Piippo A, Jääskeläinen J, Hernesniemi  J. Microsurgical clipping of cerebral aneurysms after the ISAT Study. Acta Neurochir Suppl 2005;94:3-6

2004

72. Tynninen O, Carpén O, Jääskeläinen J, Paavonen T, Paetau A. Ezrin expression in tissue microarray of primary and recurrent gliomas. Neuropathol Appl Neurobiol 2004;30:472-7

71. Frösen J, Piippo A, Paetau A, Kangasniemi M, Niemelä M, Hernesniemi J, Jääskeläinen J. Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke 2004;35:2287-93

70. Kouri M, Kankaanranta L, Seppälä T, Tervo L, Rasilainen M, Minn H, Eskola O, Vähätalo J, Paetau A, Savolainen S, Auterinen I, Jääskeläinen J, Joensuu H. Undifferentiated sinonasal carcinoma may respond to single-fraction boron neutron capture therapy. Radiother Oncol 2004;72:83-5

69. Sirén V, Antinheimo JP, Jääskeläinen J, Böhling T, Carpén O, Vaheri A. Plasminogen activation in neurofibromatosis 2-associated and sporadic schwannomas. Acta Neurochir 2004;146:111-8

68. van der Voet M, Olson JM, Kuivaniemi H, Dudek DM, Skunca M, Ronkainen A, Niemelä M, Jääskeläinen J, Hernesniemi J, Helin K, Leinonen E, Biswas M, Tromp G. Intracranial aneurysms in Finnish families: confirmation of linkage and refinement of the interval to chromosome 19q13.3. Am J Hum Genet 2004;74:564-71

2003

67. Jääskeläinen J. Non-invasive transcranial high intensity focused ultrasound (HIFUS) under MRI thermometry and guidance in the treatment of brain lesions. Acta Neurochir Suppl 2003;88:57-60

66. Jääskeläinen J, Randell T. Awake craniotomy in glioma surgery. Acta Neurochir Suppl 2003;88:31-5

65. Wills S, Ronkainen A, van der Voet M, Kuivaniemi H, Helin K, Leinonen E, Frösen J, Niemela M, Jääskeläinen J, Hernesniemi J, Tromp G. Familial intracranial aneurysms: an analysis of 346 multiplex Finnish families. Stroke 2003;34:1370-4

64. Joensuu H, Kankaanranta L, Seppälä T, Auterinen I, Kallio M, Kulvik M, Laakso J, Vähätalo J, Kortesniemi M, Kotiluoto P, Serén T, Karila J, Brander A, Järviluoma E, Ryynänen P, Paetau A, Ruokonen I, Minn H, Tenhunen M, Jääskeläinen J, Färkkilä M, Savolainen S. Boron neutron capture therapy of brain tumors: clinical trials at the finnish facility using boronophenylalanine. J Neurooncol 2003;62:123-34

63. Westphal M, Hilt DC, Bortey E, Delavault P, Olivares R, Warnke PC, Whittle IR, Jääskeläinen J, Ram Z. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro Oncol 2003;5:79-88

62. Kulvik M, Vähätalo J, Buchar E, Färkkilä M, Järviluoma E, Jääskeläinen J, Kriz O, Laakso J, Rasilainen M, Ruokonen I, Kallio M. Clinical implementation of  4-dihydroxyborylphenylalanine synthesised by an asymmetric pathway. Eur J Pharm Sci 2003;18:155-63

61. Vuorinen V, Hinkka S, Färkkilä M, Jääskeläinen J. Debulking or biopsy of malignant glioma in elderly people - a randomised study. Acta Neurochir 2003;145:5-10

2002

60. Black P, Jaaskelainen J, Chabrerie A, Golby A, Gugino L. Minimalist approach: functional mapping. Clin Neurosurg 2002;49:90-102

59. Lemeta S, Aalto Y, Niemelä M, Jääskeläinen J, Sainio M, Kere J, Knuutila S, Böhling T. Recurrent DNA sequence copy losses on chromosomal arm 6q in capillary hemangioblastoma. Cancer Genet Cytogenet 2002;133:174-8

2001

58. Surma-aho O, Niemelä M, Vilkki J, Kouri M, Brander A, Salonen O, Paetau A, Kallio M, Pyykkönen J, Jääskeläinen J. Adverse long-term effects of brain radiotherapy in adult low-grade glioma patients. Neurology 2001;56:1285-90

57. Niemelä M, Mäenpää H, Salven P, Summanen P, Poussa K, Laatikainen L, Jääskeläinen J, Joensuu H. Interferon alpha-2a therapy in 18 hemangioblastomas. Clin Cancer Res 2001;7:510-6

56. Mäkelä JP, Kirveskari E, Seppä M, Hämäläinen M, Forss N, Avikainen S, Salonen O, Salenius S, Kovala T, Randell T, Jääskeläinen J, Hari R. Three-dimensional integration of brain anatomy and function to facilitate intraoperative navigation around the sensorimotor strip. Hum Brain Mapp 2001;12:180-92

2000

55. Antinheimo J, Sallinen SL, Sallinen P, Haapasalo H, Helin H, Horelli-Kuitunen N, Wessman M, Sainio M, Jääskeläinen J, Carpén O. Genetic aberrations in sporadic and neurofibromatosis 2 (NF2)-associated schwannomas studied by comparative genomic hybridization (CGH). Acta Neurochir 2000;142:1099-104

54. Kivelä T, Jääskeläinen J, Vaheri A, Carpén O. Ezrin, a membrane-organizing protein, as a polarization marker of the retinal pigment epithelium in vertebrates. Cell Tissue Res 2000;301:217-23

53. Niemelä M, Lemeta S, Sainio M, Rauma S, Pukkala E, Kere J, Böhling T, Laatikainen L, Jääskeläinen J, Summanen P. Hemangioblastomas of the retina: impact of von Hippel-Lindau disease. Invest Ophthalmol Vis Sci 2000;41:1909-15

52. Sainio M, Jääskeläinen J, Pihlaja H, Carpén O. Mild familial neurofibromatosis 2 associates with expression of merlin with altered COOH-terminus. Neurology 2000;54:1132-8

51. Antinheimo J, Sankila R, Carpén O, Pukkala E, Sainio M, Jääskeläinen J. Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas. Neurology 2000;54:71-6

50. Niemelä M, Lemeta S, Summanen P, Böhling T, Sainio M, Kere J, Poussa K, Sankila R, Haapasalo H, Kääriäinen H, Pukkala E, Jääskeläinen J. Long-term prognosis of haemangioblastoma of the CNS: impact of von Hippel-Lindau disease. Acta Neurochir 1999;141:1147-56

49. Bondestam S, Halavaara JT, Jääskeläinen JE, Kinnunen JJ, Hamberg LM. Perfusion CT of the brain in the assessment of flow alterations during brachytherapy of meningioma. Acta Radiol 1999;40:469-73

48. Aronen HJ, Ramadan UA, Peltonen TK, Markkola AT, Tanttu JI, Jääskeläinen J, Häkkinen AM, Sepponen R. 3D spin-lock imaging of human gliomas. Magn Reson Imaging 1999;17:1001-10

47. Tynninen O, Aronen HJ, Ruhala M, Paetau A, Von Boguslawski K, Salonen O, Jääskeläinen J, Paavonen T. MRI enhancement and microvascular density in gliomas. Correlation with tumor cell proliferation. Invest Radiol 1999;34:427-34

46. Haapasalo H, Sallinen S, Sallinen P, Helén P, Jääskeläinen J, Salmi TT, Paetau A, Paljärvi L, Visakorpi T, Kalimo H. Clinicopathological correlation of cell proliferation, apoptosis and p53 in cerebellar pilocytic astrocytomas. Neuropathol Appl Neurobiol 1999;25:134-42

45. Majander-Nordenswan P, Sainio M, Turunen O, Jääskeläinen J, Carpén O, Kere J, Vaheri A. Genomic structure of the human ezrin gene. Hum Genet 1998;103:662-5

44. Turunen O, Sainio M, Jääskeläinen J, Carpén O, Vaheri A. Structure-function relationships in the ezrin family and the effect of tumor-associated point mutations in neurofibromatosis 2 protein. Biochim Biophys Acta 1998;1387:1-16

43. Seppälä MT, Sainio MA, Haltia MJ, Kinnunen JJ, Setälä KH, Jääskeläinen JE. Multiple schwannomas: schwannomatosis or neurofibromatosis type 2? J Neurosurg 1998;89:36-41

42. Sainio M, Zhao F, Heiska L, Turunen O, den Bakker M, Zwarthoff E, Lutchman M, Rouleau GA, Jääskeläinen J, Vaheri A, Carpén O. Neurofibromatosis 2 tumor suppressor protein colocalizes with ezrin and CD44 and associates with actin-containing cytoskeleton. J Cell Sci 1997;110:2249-60

41. Vaheri A, Carpén O, Heiska L, Helander TS, Jääskeläinen J, Majander-Nordenswan P, Sainio M, Timonen T, Turunen O. The ezrin protein family: membrane-cytoskeleton interactions and disease associations. Curr Opin Cell Biol 1997;9:659-66

40. Antinheimo J, Haapasalo H, Haltia M, Tatagiba M, Thomas S, Brandis A, Sainio M, Carpen O, Samii M, Jääskeläinen J. Proliferation potential and histological features in neurofibromatosis 2-associated and sporadic meningiomas. J Neurosurg 1997;87:610-4

39. Mäenpää A, Kovanen PE, Paetau A, Jäáskeläinen J, Timonen T. Lymphocyte adhesion molecule ligands and extracellular matrix proteins in gliomas and normal brain: expression of VCAM-1 in gliomas. Acta Neuropathol 1997;94:216-25

38. Ramadan UA, Aronen HJ, Tanttu JI, Karjalainen PT, Kairemo KJ, Jääskeläinen J, Sipilä L, Häkkinen AM. Improvement of brain lesion detection at 0.1 T by simultaneous use of Gd-DTPA and magnetization transfer imaging. Magn Reson Med 1997;37(2):268-74

37. Hatva E, Jääskeläinen J, Hirvonen H, Alitalo K, Haltia M. Tie endothelial cell-specific receptor tyrosine kinase is upregulated in the vasculature of arteriovenous malformations. J Neuropathol Exp Neurol 1996;55:1124-33

36. Blomstedt GC, Katila H, Henriksson M, Ekholm A, Jääskeläinen JE, Pyykko I. Depression after surgery for acoustic neuroma. J Neurol Neurosurg Psychiatry 1996;61:403-6

35. Niemelä M, Lim YJ, Söderman M, Jääskeläinen J, Lindquist C. Gamma knife radiosurgery in 11 hemangioblastomas. J Neurosurg 1996;85:591-6

34. Aronen HJ, Peltonen TK, Tanttu JI, Sipilä LM, Ruhala MT, Jääskeläinen J, Sepponen R. Spin-lock imaging in contrast-enhanced magnetic resonance imaging of human gliomas. Acad Radiol 1996;3 Suppl 2:S170-2

33. Hatva E, Böhling T, Jääskeläinen J, Persico MG, Haltia M, Alitalo K. Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. Am J Pathol 1996;148:763-75

32. Böhling T, Turunen O, Jääskeläinen J, Carpen O, Sainio M, Wahlström T, Vaheri A, Haltia M. Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. Am J Pathol 1996;148:367-73

31. Vuorinen V, Sallinen P, Haapasalo H, Visakorpi T, Kallio M, Jääskeläinen J. Outcome of 31 intracranial haemangiopericytomas: poor predictive value of cell proliferation indices. Acta Neurochir 1996;138:1399-408

30. Vuorinen V, Heikkonen J, Brander A, Setälä K, Sane T, Randell T, Paetau A, Pohjola J, Mäntylä M, Jääskeläinen J. Interstitial radiotherapy of 25 parasellar/clival meningiomas and 19 meningiomas in the elderly. Analysis of short-term tolerance and responses. Acta Neurochir 1996;138:495-508

29. Antinheimo J, Haapasalo H, Seppälä M, Sainio M, Carpen O, Jääskeläinen J. Proliferative potential of sporadic and neurofibromatosis 2-associated schwannomas as studied by MIB-1 (Ki-67) and PCNA labeling. J Neuropathol Exp Neurol 1995;54:776-82

28. Seppälä MT, Haltia MJ, Sankila RJ, Jääskeläinen JE, Heiskanen O. Long-term outcome after removal of spinal schwannoma: a clinicopathological study of 187 cases. J Neurosurg 1995;83:621-6

27. Sainio M, Strachan T, Blomstedt G, Salonen O, Setälä K, Palotie A, Palo J, Pyykkö I, Peltonen L, Jääskeläinen J. Presymptomatic DNA and MRI diagnosis of neurofibromatosis 2 with mild clinical course in an extended pedigree. Neurology 1995;45:1314-22

26. Seppälä MT, Haltia MJ, Sankila RJ, Jääskeläinen JE, Heiskanen O. Long-term outcome after removal of spinal neurofibroma. J Neurosurg 1995;82:572-7

25. Hatva E, Kaipainen A, Mentula P, Jääskeläinen J, Paetau A, Haltia M, Alitalo K. Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors. Am J Pathol 1995;146:368-78

24. Leppälä J, Kallio M, Nikula T, Nikkinen P, Liewendahl K, Jääskeläinen J, Savolainen S, Gylling H, Hiltunen J, Callaway J, et al. Accumulation of 99mTc-low-density lipoprotein in human malignant glioma. Br J Cancer 1995;71:383-7

23. Blomstedt GC, Jääskeläinen JE, Pyykkö I, Ishizaki H, Troupp H, Palva T. Recovery of the sutured facial nerve after removal of acoustic neuroma in patients with neurofibromatosis-2. Neurosurgery 1994;35:364-8

22. Färkkilä M, Jääskeläinen J, Kallio M, Blomstedt G, Raininko R, Virkkunen P, Paetau A, Sarelin H, Mäntylä M. Randomised, controlled study of intratumoral recombinant gamma-interferon treatment in newly diagnosed glioblastoma. Br J Cancer 1994;70:138-41

21. Jääskeläinen J, Paetau A, Pyykkö I, Blomstedt G, Palva T, Troupp H. Interface between the facial nerve and large acoustic neurinomas. Immunohistochemical study of the cleavage plane in NF2 and non-NF2 cases. J Neurosurg 1994;80:541-7

20. Timonen T, Jääskeläinen J, Mäenpää A, Helander T, Malygin A, Kovanen P. Growth requirements, binding and migration of human natural killer cells. Immunol Ser 1994;61:63-73. Review

19. Mäenpää A, Jääskeläinen J, Carpén O, Patarroyo M, Timonen T. Expression of integrins and other adhesion molecules on NK cells; impact of IL-2 on short- and  long-term cultures. Int J Cancer 1993;53:850-5

18. Sankila R, Kallio M, Jääskeläinen J, Hakulinen T. Long-term survival of 1986 patients with intracranial meningioma diagnosed from 1953 to 1984 in Finland. Comparison of the observed and expected survival rates in a population-based series. Cancer 1992;70:1568-76

17. Kallio M, Sankila R, Hakulinen T, Jääskeläinen J. Factors affecting operative and excess long-term mortality in 935 patients with intracranial meningioma. Neurosurgery 1992;31:2-12

16. Jääskeläinen J, Mäenpää A, Patarroyo M, Gahmberg CG, Somersalo K, Tarkkanen J, Kallio M, Timonen T. Migration of recombinant IL-2-activated T and natural killer cells in the intercellular space of human H-2 glioma spheroids in vitro. A study on adhesion molecules involved. J Immunol 1992;149:260-8

15. Kallio M, Sankila R, Jääskeläinen J, Karjalainen S, Hakulinen T. A population-based study on the incidence and survival rates of 3857 glioma patients diagnosed from 1953 to 1984. Cancer 1991;68:1394-400

14. Jääskeläinen J, Pyykkö I, Blomstedt G, Porras M, Palva T, Troupp H. Functional results of facial nerve suture after removal of acoustic neurinoma: analysis of 25 cases. Neurosurgery 1990;27:408-11

13. Jääskeläinen J, Lehtonen E, Heikkilä P, Kalliomäki P, Timonen T. Damage to multicellular human H-2 glioma spheroids incubated with LAK cells: an ultrastructural study. J Natl Cancer Inst 1990;82:497-501

12. Servo A, Porras M, Jääskeläinen J, Paetau A, Haltia M. Computed tomography and angiography do not reliably discriminate malignant meningiomas from benign ones. Neuroradiology 1990;32:94-7

11. Timonen T, Lehtovirta P, Gripenberg J, Sarlomo-Rikala M, Jääskeläinen J, Saksela E. Interleukin-2 activated lymphocytes (LAK cells) as potential tumor tracers. Acta Radiol Suppl 1990;374:109-11

10. Jääskeläinen J, Kalliomäki P, Paetau A, Timonen T. Effect of LAK cells against three-dimensional tumor tissue. In vitro study using multi-cellular human glioma spheroids as targets. J Immunol 1989;142:1036-45

9. Jääskeläinen J, Kalliomäki P, Paetau A, Saksela E, Timonen T. Cyst fluid of glioma does not inhibit the killing action of lymphokine-activated killer (LAK) cells in vitro. Acta Neurochir 1988;91:73-8

8. Jääskeläinen J. Seemingly complete removal of histologically benign intracranial meningioma: late recurrence rate and factors predicting recurrence in 657 patients. A multivariate analysis. Surg Neurol 1986 ;26:461-9

7. Jääskeläinen J, Haltia M, Servo A. Atypical and anaplastic meningiomas: radiology, surgery, radiotherapy, and outcome. Surg Neurol 1986;25:233-42

6. Jääskeläinen J, Laasonen E, Kärkkäinen J, Haltia M, Troupp H. Hormone treatment of meningiomas: lack of response to medroxyprogesterone acetate (MPA). A pilot study of five cases. Acta Neurochir 1986;80:35-41

5. Jääskeläinen J, Haltia M, Laasonen E, Wahlström T, Valtonen S. The growth rate of intracranial meningiomas and its relation to histology. An analysis of 43 patients. Surg Neurol 1985;24:165-72

4. Jääskeläinen J, Servo A, Haltia M, Wahlström T, Valtonen S. Intracranial hemangiopericytoma: radiology, surgery, radiotherapy, and outcome in 21 patients. Surg Neurol 1985;23:227-36

3. Servo A, Jääskeläinen J, Wahlström T, Haltia M. Diagnosis of intracranial haemangiopericytomas with angiography and CT scanning. Neuroradiology 1985;27:38-43

2. Sulkava R, Jääskeläinen J, Paetau A, Valtonen V, Iivanainen M. Fatal Candida meningitis in a previously healthy adult. Ann Clin Res 1984;16:201-3

1. Lahtinen T, Alhava EM, Hakumäki M, Jääskeläinen J, Väänänen A, Karjalainen P. Blood flow in proximal femur of the dog determined by the local 133Xe injection method. Acta Physiol Scand 1979;106:437-40